2008

A PROTEIN-APPENDED ROTAXANE

BY

HAYTHIM HASSANEIN

MANAGER PALL THORDARSON

2

Contents

Certificate of Orignality.............................................................................................................. we Abstract...................................................................................................................................... ii Acknowledgements................................................................................................................... 3 Table of Contents....................................................................................................................... a couple of 1 . Intro............................................................................................................................ 5 installment payments on your Natural Protein-Appended Rotaxanes.................................................................................... six 3. Bioconjugate Chemistry and Rotaxanes................................................................................ 8 4. Earliest Rotaxane Activity................................................................................................... 9 your five. Rotaxanes & Nanodevices................................................................................................... 12 5. one particular Molecular Motors................................................................................................... 10 a few. 2 Molecular Shuttles................................................................................................. 12 5. 3 Molecular Muscle tissue................................................................................................. 14 your five. 4 Molecular Electronics............................................................................................ of sixteen 6. Approach and Synthesis....................................................................................................... 17 six. 1 Pre-assembly in nonaqueous Solvents............................................................... 18 6. two Axial Component Motifs...................................................................................... 18 6. three or more Macrocycle Component Motifs............................................................................ 18 6. 5 Stopper Element Motifs................................................................................... 20 6. your five Approaches........................................................................................................... twenty 6. six Characterisaiton.................................................................................................... 21 7. Applications......................................................................................................................... 27 several. 1 Medicine Delivery........................................................................................................ 28 7. a couple of Biosensor Applications.......................................................................................... 28 almost 8. Experimental........................................................................................................................ 31 8. 1 Azo-based Reactions........................................................................................ 30 almost eight. 1 . you 8. 1 . 2 Activity of 5, 4-Azodiphenol (1)........................................................ 30 Activity of 4-Bromobutoxy Nitrobenzene (2).................................. 31

3

8. 1 ) 3 almost eight. 1 . 4

Synthesis of trans-Bis-(E)-((Bromobutoxy)phenyl)diazene) (3)........ 31 Synthesis of trans-4, 4'-Bis((6-hydroxyhexoxy)azobenzene) (4)......... 32

almost 8. 1 . 5 Attempted Activity of trans-4, 4‟-Bis((6maleimidohexoxy)azobenzne) (5)................................................................... 32 almost 8. 2 Viologen-Based Reactions............................................................................... 33 8. installment payments on your 1 Activity of four, 4‟-Bipyridinium-N, N-di(propylammonia) hexaflurophosphate...

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